Read across approach toxicology

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August undefined, 2024

WebMar 27, 2024 · We developed Generalized Read-Across (GenRA) ( Shah et al., 2016) for automated read-across prediction of a property of a chemical (called the target) as a similarity weighted average of the same property from analogues (also referred to as source analogues) ( Low et al., 2013 ). WebNov 12, 2024 · Chemical grouping and read-across Chemical grouping and read-across approaches take advantage of structural similarities between substances with known toxicology profiles and new chemical entities to infer the expected toxicological behaviour of the latter. 101 This strategy is commonly used in regulatory toxicology as an …

Molecular Similarity in Computational Toxicology SpringerLink

WebJul 12, 2013 · The Chemical–Biological Read-Across (CBRA) approach infers each compound’s toxicity from both chemical and biological analogues whose similarities are … WebJul 12, 2013 · Advancing the science of a read-across framework for evaluation of data-poor chemicals incorporating systematic and new approach methods. Regulatory Toxicology and Pharmacology 2024, 137 , 105293. ... Extending the Generalised Read-Across approach (GenRA): A systematic analysis of the impact of physicochemical property information on … in a root hair cell what part absorbs water

(PDF) Internationalization of read-across as a validated new …

WebJoin us for a Generalized Read Across (GenRA) Virtual Training May 23, 2024 11:00 a.m. – 1:30 p.m. EDT The US Environmental Protection Agency (EPA)'s Generalized Read-Across (GenRA) tool is a freely-available, automated approach to make reproducible read-across predictions of toxicity outcomes. This training will include: A presentation overview of … WebRead-across has generated much attention since it may be used as an alternative approach for addressing the information requirements under regulatory programmes, notably the EU's REACH regulation. WebJul 8, 2024 · Inspired by the increasingly used read-across approach, we created a new type of QSAR, which is based on similarity of chemicals and not on chemical descriptors. A landscape of the chemical universe using 10 million structures was calculated, when based on Tanimoto indices similar chemicals are close and dissimilar chemicals far from each … in a root hair cell what absorbs water

Generalised Read-Across GenRA, research, implementation …

Read-Across Assessment Framework (RAAF) - Europa

WebFeb 6, 2024 · Toxicology and Environmental Research and Consulting, Dow Chemical, Midland, Michigan, USA. Search for more papers by this author. Lennart Weltje, ... In addition, the degree of validation needed to provide sufficient confidence in a given read-across approach has to be decided. Another complicating factor is the difference in validation ... WebRead-across is one approach frequently used in the risk assessment of substances that lack information on their physical-chemical or toxicological properties, or their environmental … inam ghani twitterWebNov 28, 2024 · Read-across is one of the most frequently used alternative tools for hazard assessment, in particular for complex endpoints such as repeated dose or developmental … in a root hair cell but not in a liver cell

"WebJun 23, 2024 · The concept of chemical similarity has many applications in several fields of cheminformatics. One common use of chemical similarity measurements, based on the principle that similar molecules have similar properties, is in the context of the read-across approach, where estimates of a specific endpoint for a chemical are obtained starting … " - Read across approach toxicology

Read across approach toxicology

Approaches in metabolomics for regulatory toxicology applications …

WebCategory formation, grouping and read across methods are broadly applicable in toxicological assessments and may be used to fill data gaps for chemical safety … WebRead-across is one of the most frequently used alternative tools for hazard assessment, in particular for complex endpoints such as repeated dose or developmental and reproductive toxicity. Read-across extrapolates the outcome of a specific toxicological in vivo endpoint from tested (source) compounds to "similar" (target) compound (s).

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WebWe present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active … Weba National Center for Computational Toxicology (NCCT), ... any read-across approach should be broadly based in scope or lim-ited to a speciﬁc endpoint. Patlewicz et al. [39,40] discussed the ...

WebThe use of toxicity data on a structurally-similar compound to evaluate a substance that has been inadequately tested – the so-called “read-across” approach – is a crucial part of the … Web• Computational toxicologist expert in in silico chemical safety assessment • Professional expertise in generating (eco)toxicological and physicochemical data by means of in silico approaches (QSAR, expert systems and read-across) in compliance with the current regulations (e.g., REACH, CLP, ICH M7 guideline, Biocides and Cosmetics …

Webread-across hypothesis and the information requirement to be read across The RAAF defines two general read-across hypotheses: 1. (Bio)transformation into a common toxicant • Toxicokinetic information may support the approach 2. Different compounds have the same type of effects • Toxicodynamic information may support the approach Web1 day ago · Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury …

Webproposed read-across case, resulting in an output which is suitable for subsequent regulatory consideration of the read-across case. The approach reflects both a need to …

WebApr 30, 2024 · defines grouping of substances and read-across approach as: “ Substances whose physicochemical, toxicological and ecotoxicological properties are likely to be … inam ghous aliWebDec 1, 2024 · Advancing the science of a read-across framework for evaluation of data-poor chemicals incorporating systematic and new approach methods Regulatory Toxicology and Pharmacology, Volume 137, 2024, Article 105293 Show abstract Research article Nitrocellulose blister material as a source of N-nitrosamine contamination of … in a rotameter the flow is measured atWebToxicology Letters 116(S1), 61. Potts RO, Guy RH. (1992). Predicting skin permeability. ... The UK Environmental Agency have a similar approach to read across as the HSE though appropriate ecotoxicity tests such as acute toxicity to Daphnia form the basis of establishing the validity of their read acrosses.The approach is also a step-by-step ... inam foundationWebJan 1, 2024 · Integrating computational chemistry and toxicology can improve the read-across analog approach to fill data gaps in chemical safety assessment. ... The read-across approach starts with structural ... inam hermosilloWebRead-across describes one of the techniques for filling data gaps in either the analogue or category approaches i.e. not to be confused with the “analogue approach” – “Analogue … inam foundation for autismWebComputational Toxicology. Background & definitions • Read-across describes one of the data gap filling techniques used within analogue and category approaches • “Analogue approach” refers to grouping based on a very limited number of chemicals (e.g. target substance) + source substance) • “Category approach” is used when grouping ... in a roomful of bluesWebSep 26, 2024 · A read-across assessment is using the technique of predicting toxicity data for one compound, named as target compound (TC), by using data for the same endpoint … in a rough manner