Cisplatin ddtc
WebRats treated with cisplatin and then DDTC did not show a significant elevation of hearing threshold. DDTC-mediated protection was associated with higher levels of GSH (0.81 +/- 0.11 nmol/mg tissue), compared to 0.45 +/- 0.02 nmol/mg tissue following administration of cisplatin alone.
Cisplatin ddtc
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WebNov 1, 2008 · Methods: Cis-Diamminedichloroplatinum (II) (DDP) was measured in protein precipitated plasma with Ice cold ethanol following … WebJan 15, 2024 · Cisplatin Targeted-therapy Abbreviations 18F-FDG 2-deoxy-2- (18F) fluoro- d -glucose AFM atomic force microscopy ALT alanine transaminase ANOVA analysis of variance AST aspartate transaminase ATCC American Type Culture Collection AUC area under the curve BUN blood urea nitrogen DDTC diethyldithiocarbamate DMEM …
WebApr 25, 2003 · Cisplatin, mesna (sodium 2-mercaptoethanesulfonate), sodium diethyldithiocarbamate (DDTC), GSH and GSSG were obtained from Sigma Chemicals (St. Louis, Mo.). TS was obtained from Brocacef (Maarssen, The Netherlands). 4- (2-Hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) was purchased from ICN … WebDiethyldithiocarbamate (DDTC), a chelating agent that is a major metabolite of disulfuram, has been proposed as a potential rescue agent to reduce toxicity following high-dose …
WebCisplatin and the internal standard trans-diamminedichloropalladium (II) (TDPD) were chelated with diethyldithiocarbamate (DDTC) and separated with an isocratic elution... Cite Similar... WebDec 9, 2024 · The cisplatin released from the nanoparticles triggered by GSH was successfully examined as [Pt (DDTC)2]⁺ (m/z 491.01) and [Pt (DDTC)3]⁺ (m/z 639.04) by MALDI-MS after derivatization using...
Webcisplatin with diethyldithiocarbamate (DDTC), which forms a platinum (Pt) complex with DDTC in different matrices, particularly cell suspensions. This Application Note shows an …
WebCisplatin is one of the most potent anticancer agent used in the treatment of various solid tumors, however, its clinical use is limited due to severe adverse effects including nephrotoxicity. In this investigation cisplatin loaded poly (lactic-co-glycolic acid) (P dates of the new moonWebJan 29, 2024 · The DDTC-cisplatin compound was then extracted by chloroform. After the chloroform layer was absorbed and the argon dried, the residue was dissolved with ethyl acetate, centrifuged for 5 min, and the supernatant was taken for further analysis. Separations using chromatography were done using an LC-20AB (SPD-20A UV-VIS … dates of the prohibition eraWebCisplatin (CDDP) is a widely used antineoplastic agent, the administration of which is associated with dose-related toxicities. Currently, ototoxicity is the dose-limiting toxicity of cisplatin and difficult to prevent. The purpose of this study was to determine the ability of two substituted dithio … dates of the second continental congressWebThis regimen of high-dose tamoxifen in combination with cisplatin can be safely administered. Serum tamoxifen levels comparable to concentrations required for enhancement of cisplatin sensitivity in vitro are clinically achievable with acceptable toxicity. The level of antitumor activity in nonsmall … bj alex changwooWebThe cisplatin released from the nanoparticles triggered by GSH was successfully examined as [Pt(DDTC) 2] + (m/z 491.01) and [Pt(DDTC) 3] + (m/z 639.04) by MALDI-MS after derivatization using … b jain books homoeopathyWebDDTC also has application as a cleaning agent for cisplatin (e.g., for production equipment cleaning, spill cleanup). Destruction of cisplatin can be affected by the reaction of … bj alex free to read onlineWebSep 15, 2011 · Cisplatin or carboplatin and gold (III) as an internal standard were derivatized by N, N -diethyldithiocarbamate (DDTC). Pt (DDTC) 3+ and Au (DDTC) 2+ were monitored by the respective transitions of m / z 639.3–490.9 and 493.0–345.0, respectively. Each separation was completed within 9 min using a 3 μm particle ODS-column. bjak office